This article provides a comprehensive analysis of the evolution of the concept of "logistics" and explores modern innovative solutions in the field of transport logistics aimed at optimizing the management of material and information flows. Theoretical approaches to the definition of logistics in foreign and domestic science are considered. Special attention is paid to the structure of logistics as a scientific discipline, among the sections of which transport logistics, its goals, objectives and role are considered in detail. The main purpose of the work is to conduct an analytical review of innovations capable of modernizing the processes of building optimal routes and cargo control during transportation, mainly by road, which dominates cargo transportation in many countries, including Russia, the United States and China. The key technological trends of the digital transformation of transport logistics are described in detail: transport management systems, cloud platforms, electronic document management, the use of Big Data technologies to optimize routes, as well as the use of IoT devices and telematics. A special emphasis in the work is placed on the analysis of the potential of unmanned technologies. Both the use of unmanned aerial vehicles for delivery to hard-to-reach areas and the introduction of unmanned trucks on highways are being considered. The article provides a brief overview of the technical components of autonomous trucks, the global experience of their use, as well as the economic efficiency of their use, confirmed by calculations and forecasts of analytical agencies.